Titre
Incidence trends of lung and gastroenteropancreatic neuroendocrine neoplasms in Switzerland.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Alwan, H.
Auteure/Auteur
La Rosa, S.
Auteure/Auteur
Andreas Kopp, P.
Auteure/Auteur
Germann, S.
Auteure/Auteur
Maspoli-Conconi, M.
Auteure/Auteur
Sempoux, C.
Auteure/Auteur
Bulliard, J.L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2045-7634
Statut éditorial
Publié
Date de publication
2020-12
Volume
9
Numéro
24
Première page
9454
Dernière page/numéro d’article
9461
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
The incidence of neuroendocrine neoplasms (NENs) seems to increase worldwide. Long-term, population-based series that consider tumor differentiation are, however, sparse. We assessed the incidence trend of lung and gastroenteropancreatic (GEP) NENs according to the latest International Agency for Research on Cancer/World Health Organization classification over a 41-year time period in two Swiss regions. All cases of lung and GEP NENs recorded in the Vaud and Neuchâtel Cancer Registries from 1976 to 2016 were included. NENs were stratified into well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Changes in annual age-standardized incidence rates were calculated for lung and GEP NETs and NECs by sex. Of 4,141 patients diagnosed with NENs, 65% were men. The incidence of lung NETs among men and women increased by 3.9%/year (95% CI: -5.3, 14.1%) and 4.9%/year (0.1, 9.9%), respectively, between 1976 and 2016. The incidence of lung NECs decreased by 2.6%/year (-3.1,-1.8%) in men from 1985 to 2016 whereas it increased in women between 1976 and 1998 by 6%/year (4.2, 7.9%). For GEP NETs, a steady annual increase in incidence occurred between 1976 and 2016 with a magnitude of 1.7% (0.7, 2.7%) in men and 1.3% (0.5, 2.1%) in women. No significant trend in incidence of GEP NECs was found for both sexes. The incidence trends of lung NECs in men and women parallel changes in smoking prevalence in the population. Causes of the increase in incidence of GEP NETs are likely multifactorial. Our study supports the importance of evaluating the epidemiology of NENs by tumor differentiation.
PID Serval
serval:BIB_05394D4A81D6
PMID
Open Access
Oui
Date de création
2020-10-21T11:24:53.648Z
Date de création dans IRIS
2025-05-20T13:22:53Z
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Nom
33078908.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
353.86 KB
Format
Adobe PDF
PID Serval
serval:BIB_05394D4A81D6.P001
URN
urn:nbn:ch:serval-BIB_05394D4A81D62
Somme de contrôle
(MD5):2bf362094dc08d7177b59ca5ecf4ddfc