Titre
Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Bassetti, M.
Auteure/Auteur
Giacobbe, D.R.
Auteure/Auteur
Grecchi, C.
Auteure/Auteur
Rebuffi, C.
Auteure/Auteur
Zuccaro, V.
Auteure/Auteur
Scudeller, L.
Auteure/Auteur
Contributrices/contributeurs
Akova, M.
Alastruey-Izquierdo, A.
Arikan-Akdagli, S.
Azoulay, E.
Blot, S.
Cornely, O.A.
Lass-Flörl, C.
Koehler, P.
Cuenca-Estrella, M.
de Lange, D.W.
De Rosa, F.G.
De Waele, J.J.
Dimopoulos, G.
Garnacho-Montero, J.
Hoenigl, M.
Kanj, S.S.
Lamoth, F.
Maertens, J.
Martin-Loeches, I.
Muñoz, P.
Kullberg, B.J.
Agvald-Ohman, C.
Poulakou, G.
Rello, J.
Righi, E.
Sanguinetti, M.
Taccone, F.S.
Timsit, J.F.
Torres, A.
Vazquez, J.A.
Wauters, J.
Calandra, T.
Asperges, E.
Tejada, S.
Lebihan, C.
Karaiskos, I.
Peghin, M.
Mortensen, K.L.
Vena, A.
Cortegiani, A.
Mercier, T.
Groupes de travail
FUNDICU investigators
Liens vers les personnes
Liens vers les unités
ISSN
1532-2742
Statut éditorial
Publié
Date de publication
2020-07
Volume
81
Numéro
1
Première page
131
Dernière page/numéro d’article
146
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review ; Systematic Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
To summarize the available evidence on the diagnostic performance for invasive aspergillosis (IA) in non-hematological, non-solid organ transplantation critically ill patients of the following: (i) existing definitions of IA (developed either for classical immunocompromised populations or for non-immunocompromised critically ill patients); (ii) laboratory tests; (iii) radiology tests.
A systematic review was performed by evaluating studies assessing the diagnostic performance for IA of a definition/s and/or laboratory/radiology test/s vs. a reference standard (histology) or a reference definition.
Sufficient data for evaluating the performance of existing definitions and laboratory tests for the diagnosis of IA in critically ill patients is available only for invasive pulmonary aspergillosis. Against histology/autopsy as reference, the AspICU definition showed a promising diagnostic performance but based on small samples and applicable only to patients with positive respiratory cultures. Studies on laboratory tests consistently indicated a better diagnostic performance of bronchoalveolar lavage fluid (BALF) galactomannan (GM) than serum GM, and a suboptimal specificity of BALF and serum (1,3)-β-D-glucan.
Evidence stemming from this systematic review will guide the discussion for defining invasive aspergillosis within the FUNDICU project. The project aims to develop a standard set of definitions for invasive fungal diseases in critically ill, adult patients.
A systematic review was performed by evaluating studies assessing the diagnostic performance for IA of a definition/s and/or laboratory/radiology test/s vs. a reference standard (histology) or a reference definition.
Sufficient data for evaluating the performance of existing definitions and laboratory tests for the diagnosis of IA in critically ill patients is available only for invasive pulmonary aspergillosis. Against histology/autopsy as reference, the AspICU definition showed a promising diagnostic performance but based on small samples and applicable only to patients with positive respiratory cultures. Studies on laboratory tests consistently indicated a better diagnostic performance of bronchoalveolar lavage fluid (BALF) galactomannan (GM) than serum GM, and a suboptimal specificity of BALF and serum (1,3)-β-D-glucan.
Evidence stemming from this systematic review will guide the discussion for defining invasive aspergillosis within the FUNDICU project. The project aims to develop a standard set of definitions for invasive fungal diseases in critically ill, adult patients.
PID Serval
serval:BIB_2A39F40A3E05
PMID
Date de création
2022-05-16T15:04:49.600Z
Date de création dans IRIS
2025-05-20T13:24:25Z