Titre
Education of Murine NK Cells Requires Both cis and trans Recognition of MHC Class I Molecules.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Bessoles, S.
Auteure/Auteur
Angelov, G.S.
Auteure/Auteur
Back, J.
Auteure/Auteur
Leclercq, G.
Auteure/Auteur
Vivier, E.
Auteure/Auteur
Held, W.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1550-6606
Statut éditorial
Publié
Date de publication
2013
Volume
191
Numéro
10
Première page
5044
Dernière page/numéro d’article
5051
Langue
anglais
Résumé
Although NK cells use invariant receptors to identify diseased cells, they nevertheless adapt to their environment, including the presence of certain MHC class I (MHC-I) molecules. This NK cell education, which is mediated by inhibitory receptors specific for MHC-I molecules, changes the responsiveness of activating NK cell receptors (licensing) and modifies the repertoire of MHC-I receptors used by NK cells. The fact that certain MHC-I receptors have the unusual capacity to recognize MHC-I molecules expressed by other cells (trans) and by the NK cell itself (cis) has raised the question regarding possible contributions of the two types of interactions to NK cell education. Although the analysis of an MHC-I receptor variant suggested a role for cis interaction for NK cell licensing, adoptive NK cell transfer experiments supported a key role for trans recognition. To reconcile some of these findings, we have analyzed the impact of cell type-specific deletion of an MHC-I molecule and of a novel MHC-I receptor variant on the education of murine NK cells when these mature under steady-state conditions in vivo. We find that MHC-I expression by NK cells (cis) and by T cells (trans), and MHC-I recognition in cis and in trans, are both needed for NK cell licensing. Unexpectedly, modifications of the MHC-I receptor repertoire are chiefly dependent on cis binding, which provides additional support for an essential role for this unconventional type of interaction for NK cell education. These data suggest that two separate functions of MHC-I receptors are needed to adapt NK cells to self-MHC-I.
PID Serval
serval:BIB_2B1B56B9E4B6
PMID
Open Access
Oui
Date de création
2013-12-07T15:37:28.382Z
Date de création dans IRIS
2025-05-20T13:57:45Z
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Nom
5044.full.pdf
Version du manuscrit
preprint
Taille
1.63 MB
Format
Adobe PDF
PID Serval
serval:BIB_2B1B56B9E4B6.P001
URN
urn:nbn:ch:serval-BIB_2B1B56B9E4B69
Somme de contrôle
(MD5):304b04e91bfe7e242c479307442246f3