Titre
Integrated genomic characterization of endometrial carcinoma.
Type
article
Institution
Externe
Périodique
Auteur(s)
Kandoth, C.
Auteure/Auteur
Schultz, N.
Auteure/Auteur
Cherniack, A.D.
Auteure/Auteur
Akbani, R.
Auteure/Auteur
Liu, Y.
Auteure/Auteur
Shen, H.
Auteure/Auteur
Robertson, A.G.
Auteure/Auteur
Pashtan, I.
Auteure/Auteur
Shen, R.
Auteure/Auteur
Benz, C.C.
Auteure/Auteur
Yau, C.
Auteure/Auteur
Laird, P.W.
Auteure/Auteur
Ding, L.
Auteure/Auteur
Zhang, W.
Auteure/Auteur
Mills, G.B.
Auteure/Auteur
Kucherlapati, R.
Auteure/Auteur
Mardis, E.R.
Auteure/Auteur
Levine, D.A.
Auteure/Auteur
Contributrices/contributeurs
Getz, G.
Gabriel, S.B.
Cibulskis, K.
Lander, E.
Sivachenko, A.
Sougnez, C.
Lawrence, M.
Kandoth, C.
Dooling, D.
Fulton, R.
Fulton, L.
Kalicki-Veizer, J.
McLellan, M.D.
O'Laughlin, M.
Schmidt, H.
Wilson, R.K.
Ye, K.
Ding, L.
Mardis, E.R.
Ally, A.
Balasundaram, M.
Birol, I.
Butterfield, Y.S.
Carlsen, R.
Carter, C.
Chu, A.
Chuah, E.
Chuah, H.J.
Dhalla, N.
Guin, R.
Hirst, C.
Holt, R.A.
Jones, S.J.
Lee, D.
Li, H.I.
Marra, M.A.
Mayo, M.
Moore, R.A.
Mungall, A.J.
Plettner, P.
Schein, J.E.
Sipahimalani, P.
Tam, A.
Varhol, R.J.
Robertson, A.
Cherniack, A.D.
Pashtan, I.
Saksena, G.
Onofrio, R.C.
Schumacher, S.E.
Tabak, B.
Carter, S.L.
Hernandez, B.
Gentry, J.
Salvesen, H.B.
Ardlie, K.
Getz, G.
Winckler, W.
Beroukhim, R.
Gabriel, S.B.
Meyerson, M.
Hadjipanayis, A.
Lee, S.
Mahadeshwar, H.S.
Park, P.
Protopopov, A.
Ren, X.
Seth, S.
Song, X.
Tang, J.
Xi, R.
Yang, L.
Zeng, D.
Kucherlapati, R.
Chin, L.
Zhang, J.
Auman, T.
Balu, S.
Bodenheimer, T.
Buda, E.
Hayes, D.
Hoyle, A.P.
Jefferys, S.R.
Jones, C.D.
Meng, S.
Mieczkowski, P.A.
Mose, L.E.
Parker, J.S.
Perou, C.M.
Roach, J.
Shi, Y.
Simons, J.V.
Soloway, M.G.
Tan, D.
Topal, M.D.
Waring, S.
Wu, J.
Hoadley, K.A.
Baylin, S.B.
Bootwalla, M.S.
Lai, P.H.
Triche, T.J.
Van Den Berg, D.J.
Weisenberger, D.J.
Laird, P.W.
Shen, H.
Chin, L.
Zhang, J.
Getz, G.
Cho, J.
DiCara, D.
Frazer, S.
Heiman, D.
Jing, R.
Lin, P.
Mallard, W.
Stojanov, P.
Voet, D.
Zhang, H.
Zou, L.
Noble, M.
Lawrence, M.
Reynolds, S.M.
Shmulevich, I.
Aksoy, B.
Antipin, Y.
Ciriello, G.
Dresdner, G.
Gao, J.
Gross, B.
Jacobsen, A.
Ladanyi, M.
Reva, B.
Sander, C.
Sinha, R.
Sumer, S.
Taylor, B.S.
Cerami, E.
Weinhold, N.
Schultz, N.
Shen, R.
Benz, S.
Goldstein, T.
Haussler, D.
Ng, S.
Szeto, C.
Stuart, J.
Benz, C.C.
Yau, C.
Zhang, W.
Annala, M.
Broom, B.M.
Casasent, T.D.
Ju, Z.
Liang, H.
Liu, G.
Lu, Y.
Unruh, A.K.
Wakefield, C.
Weinstein, J.N.
Zhang, N.
Liu, Y.
Broaddus, R.
Akbani, R.
Mills, G.B.
Adams, C.
Barr, T.
Black, A.D.
Bowen, J.
Deardurff, J.
Frick, J.
Gastier-Foster, J.M.
Grossman, T.
Harper, H.A.
Hart-Kothari, M.
Helsel, C.
Hobensack, A.
Kuck, H.
Kneile, K.
Leraas, K.M.
Lichtenberg, T.M.
McAllister, C.
Pyatt, R.E.
Ramirez, N.C.
Tabler, T.R.
Vanhoose, N.
White, P.
Wise, L.
Zmuda, E.
Barnabas, N.
Berry-Green, C.
Blanc, V.
Boice, L.
Button, M.
Farkas, A.
Green, A.
MacKenzie, J.
Nicholson, D.
Kalloger, S.E.
Gilks, C.B.
Karlan, B.Y.
Lester, J.
Orsulic, S.
Borowsky, M.
Cadungog, M.
Czerwinski, C.
Huelsenbeck-Dill, L.
Iacocca, M.
Petrelli, N.
Rabeno, B.
Witkin, G.
Nemirovich-Danchenko, E.
Potapova, O.
Rotin, D.
Berchuck, A.
Birrer, M.
DiSaia, P.
Monovich, L.
Curley, E.
Gardner, J.
Mallery, D.
Penny, R.
Dowdy, S.C.
Winterhoff, B.
Dao, L.
Gostout, B.
Meuter, A.
Teoman, A.
Dao, F.
Olvera, N.
Bogomolniy, F.
Garg, K.
Soslow, R.A.
Levine, D.A.
Abramov, M.
Bartlett, J.M.
Kodeeswaran, S.
Parfitt, J.
Moiseenko, F.
Clarke, B.A.
Goodman, M.T.
Carney, M.E.
Matsuno, R.K.
Fisher, J.
Huang, M.
Rathmell, W.
Thorne, L.
Van Le, L.
Dhir, R.
Edwards, R.
Elishaev, E.
Zorn, K.
Broaddus, R.
Goodfellow, P.J.
Mutch, D.
Schultz, N.
Liu, Y.
Akbani, R.
Cherniack, A.D.
Cerami, E.
Weinhold, N.
Shen, H.
Hoadley, K.A.
Kahn, A.B.
Bell, D.W.
Pollock, P.M.
Wang, C.
Wheeler, D.A.
Shinbrot, E.
Karlan, B.Y.
Berchuck, A.
Dowdy, S.C.
Winterhoff, B.
Goodman, M.T.
Robertson, A.
Beroukhim, R.
Pashtan, I.
Salvesen, H.B.
Laird, P.W.
Noble, M.
Stuart, J.
Ding, L.
Kandoth, C.
Gilks, C.
Soslow, R.A.
Goodfellow, P.J.
Mutch, D.
Broaddus, R.
Zhang, W.
Mills, G.B.
Kucherlapati, R.
Mardis, E.R.
Levine, D.A.
Ayala, B.
Chu, A.L.
Jensen, M.A.
Kothiyal, P.
Pihl, T.D.
Pontius, J.
Pot, D.A.
Snyder, E.E.
Srinivasan, D.
Kahn, A.B.
Shaw, K.R.
Sheth, M.
Davidsen, T.
Eley, G.
Ferguson, M.L.
Demchok, J.A.
Yang, L.
Guyer, M.S.
Ozenberger, B.A.
Sofia, H.J.
Groupes de travail
Cancer Genome Atlas Research Network
Liens vers les personnes
ISSN
1476-4687
Statut éditorial
Publié
Date de publication
2013-05-02
Volume
497
Numéro
7447
Première page
67
Dernière page/numéro d’article
73
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Publication Status: ppublish
Résumé
We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ∼25% of high-grade endometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequent TP53 mutations. Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B. A subset of endometrioid tumours that we identified had a markedly increased transversion mutation frequency and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours.
Sujets
PID Serval
serval:BIB_3261EC88BD7B
PMID
Open Access
Oui
Date de création
2018-07-06T10:02:53.621Z
Date de création dans IRIS
2025-05-20T14:06:26Z