Titre
From secondary to tertiary mitral regurgitation: the paradigm shifts, but uncertainties remain.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Landi, A.
Auteure/Auteur
Faletra, F.F.
Auteure/Auteur
Pavon, A.G.
Auteure/Auteur
Pedrazzini, G.
Auteure/Auteur
Valgimigli, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2047-2412
Statut éditorial
Publié
Date de publication
2021-07-20
Volume
22
Numéro
8
Première page
835
Dernière page/numéro d’article
843
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Secondary mitral regurgitation (MR) is the most common and undertreated form of MR, whose contribution to poor prognosis and indications to correction remains under discussion. MR has been characterized into 'proportionate' or 'disproportionate', based on left ventricle (LV) and regurgitant volumes, whereas 'tertiary' MR identifies conditions, in which regurgitation is pathologic per se and actively contributes to LV dysfunction. Echocardiographic and anatomo-pathological studies revealed that secondary MR prompts subtle leaflet maladaptive changes, actively contributing to the dynamic progression of secondary MR. We critically discuss the paradigm shift from secondary to tertiary MR and question the notion that MV leaflets play a passive role in secondary MR. We also review the role of standard transthoracic echocardiography for appraising and quantifying maladaptive MV leaflet changes and LV volumes and call for a more sophisticated and comprehensive imaging framework for classifying MR in future interventional studies.
PID Serval
serval:BIB_34504024C241
PMID
Date de création
2021-05-29T14:09:20.274Z
Date de création dans IRIS
2025-05-20T14:26:10Z