Titre
Pressure-derived measurement of coronary flow reserve.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
MacCarthy, P.
Auteure/Auteur
Berger, A.
Auteure/Auteur
Manoharan, G.
Auteure/Auteur
Bartunek, J.
Auteure/Auteur
Barbato, E.
Auteure/Auteur
Wijns, W.
Auteure/Auteur
Heyndrickx, G.R.
Auteure/Auteur
Pijls, N.H.
Auteure/Auteur
De Bruyne, B.
Auteure/Auteur
Liens vers les unités
ISSN
0735-1097
Statut éditorial
Publié
Date de publication
2005
Volume
45
Numéro
2
Première page
216
Dernière page/numéro d’article
220
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
OBJECTIVES: We aimed to validate the technique of measuring the coronary flow reserve (CFR) with coronary pressure measurements against an established thermodilution technique. BACKGROUND: The CFR has traditionally required measurement of coronary blood flow velocity with the Doppler wire and, more recently, using a thermodilution technique with the coronary pressure wire. However, recent work has suggested that the CFR may be derived from pressure measurements alone (the ratio of the square root of the pressure drop across an epicardial stenosis during hyperemia to that value at rest). This depends on the assumption that friction losses across a coronary stenosis are negligible. METHODS: We compared pressure-derived CFR values with those obtained by the thermodilution technique using the intracoronary pressure wire in 38 stenoses in 34 patients with significant coronary stenoses undergoing percutaneous intervention. We also compared these two techniques of measuring CFR in 25 stenoses (6 vessels) artificially created by inflating small balloons within a stented coronary artery after percutaneous intervention. RESULTS: There is a close linear relationship between pressure-derived and thermodilution CFR in native (r(2) = 0.52; p < 0.001) and artificial stenoses (r(2) = 0.54; p < 0.05), although the pressure-derived technique appears to systematically underestimate CFR values in both situations. This applies to native and artificial stenoses. CONCLUSIONS: Coronary flow reserve cannot be measured merely with pressure alone, and it cannot be safely assumed that friction losses are negligible across a native coronary stenosis. These data suggest that friction loss is an important determinant of the pressure gradient along an atherosclerotic coronary artery.
PID Serval
serval:BIB_38260
PMID
Open Access
Oui
Date de création
2007-11-19T11:36:36.699Z
Date de création dans IRIS
2025-05-20T14:34:13Z