Titre
Steroid-sensitive nephrotic syndrome: from childhood to adulthood
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Fakhouri, F.
Auteure/Auteur
Bocquet, N.
Auteure/Auteur
Taupin, P.
Auteure/Auteur
Presne, C.
Auteure/Auteur
Gagnadoux, M. F.
Auteure/Auteur
Landais, P.
Auteure/Auteur
Lesavre, P.
Auteure/Auteur
Chauveau, D.
Auteure/Auteur
Knebelmann, B.
Auteure/Auteur
Broyer, M.
Auteure/Auteur
Grunfeld, J. P.
Auteure/Auteur
Niaudet, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1523-6838
Statut éditorial
Publié
Date de publication
2003-03
Volume
41
Numéro
3
Première page
550
Dernière page/numéro d’article
7
Langue
anglais
Notes
Fakhouri, Fadi
Bocquet, Nathalie
Taupin, Pierre
Presne, Claire
Gagnadoux, Marie-France
Landais, Paul
Lesavre, Philippe
Chauveau, Dominique
Knebelmann, Bertrand
Broyer, Michel
Grunfeld, Jean-Pierre
Niaudet, Patrick
eng
Am J Kidney Dis. 2003 Mar;41(3):550-7. doi: 10.1053/ajkd.2003.50116.
Bocquet, Nathalie
Taupin, Pierre
Presne, Claire
Gagnadoux, Marie-France
Landais, Paul
Lesavre, Philippe
Chauveau, Dominique
Knebelmann, Bertrand
Broyer, Michel
Grunfeld, Jean-Pierre
Niaudet, Patrick
eng
Am J Kidney Dis. 2003 Mar;41(3):550-7. doi: 10.1053/ajkd.2003.50116.
Résumé
BACKGROUND: The clinical presentation, treatment, and outcome of steroid-sensitive nephrotic syndrome (SSNS) during childhood have been extensively studied. Conversely, few data regarding the outcome in adulthood of childhood SSNS have been published previously. We undertook to conduct a retrospective study of the outcome in adulthood of a large cohort of patients diagnosed with an SSNS during childhood. METHODS: We identified all children born between 1970 and 1975 who had been admitted to our institution for an SSNS. Data regarding the outcome in adulthood of these patients were obtained through mailed questionnaires or phone calls to patients and/or their parents or through attending physicians. RESULTS: One hundred seventeen patients were identified. Data regarding the outcome of SSNS in adulthood were available for 102 patients (87.2%). Forty-three patients (42.2%) experienced at least one relapse of nephrotic syndrome in adulthood. By univariate analysis, young age at onset (<6 years) and more severe disease in childhood, indicated by a greater number of relapses (12.9 for adulthood relapsers versus 5.4 for adulthood nonrelapsers; P < 0.0001) and more frequent use of immunosuppressors (74.4% versus 31.6%; P < 0.0001) or cyclosporine (42.9% versus 7.3%; P < 0.0001) were predictive of the occurrence of SSNS relapse in adulthood. Conversely, relapse rate in the first 6 months of disease was not predictive of further relapses in adulthood. By multivariate analysis, only number of relapses during childhood was predictive of adulthood relapses (P < 0.0058). Long-term side effects of steroids were found in 44.2% of adulthood relapsers; the most frequent were osteoporosis and excess weight. CONCLUSION: The incidence of childhood SSNS relapses in adulthood was relatively high in our study. Further studies are required to assess long-term complications in adults with relapses and a history of prolonged steroid and immunosuppressor use.
PID Serval
serval:BIB_0130C13F21BF
PMID
Date de création
2022-03-01T09:18:32.602Z
Date de création dans IRIS
2025-05-20T14:36:24Z