Titre
Effects of aripiprazole, risperidone, and olanzapine on 5-HT1A receptors in patients with schizophrenia
Type
article
Institution
Externe
Périodique
Auteur(s)
Lerond, J.
Auteure/Auteur
Lothe, A.
Auteure/Auteur
Ryvlin, P.
Auteure/Auteur
Bouvard, S.
Auteure/Auteur
d'Amato, T.
Auteure/Auteur
Ciumas, C.
Auteure/Auteur
Dalery, J.
Auteure/Auteur
Poulet, E.
Auteure/Auteur
Saoud, M.
Auteure/Auteur
Liens vers les personnes
ISSN
1533-712X
Statut éditorial
Publié
Date de publication
2013-02
Volume
33
Numéro
1
Première page
84
Dernière page/numéro d’article
9
Langue
anglais
Notes
Lerond, Jerome
Lothe, Amelie
Ryvlin, Philippe
Bouvard, Sandrine
d'Amato, Thierry
Ciumas, Carolina
Dalery, Jean
Poulet, Emmanuel
Saoud, Mohamed
eng
Comparative Study
Research Support, Non-U.S. Gov't
J Clin Psychopharmacol. 2013 Feb;33(1):84-9. doi: 10.1097/JCP.0b013e31827b97a6.
Lothe, Amelie
Ryvlin, Philippe
Bouvard, Sandrine
d'Amato, Thierry
Ciumas, Carolina
Dalery, Jean
Poulet, Emmanuel
Saoud, Mohamed
eng
Comparative Study
Research Support, Non-U.S. Gov't
J Clin Psychopharmacol. 2013 Feb;33(1):84-9. doi: 10.1097/JCP.0b013e31827b97a6.
Résumé
To investigate the impact of various antipsychotic drugs on the 5-HT1A serotoninergic system, we performed a [F]4-(2-methoxyphenyl)-1-[2-(N-2-pirydynyl)-p-luorobenzamido]-ethyl-piperazine PET study in 19 schizophrenic patients treated with either aripiprazole, which has a partial agonist activity at 5-HT1A receptors, or second-generation antipsychotics (SGA) (olanzapine or risperidone), which do not demonstrate such property. We used a simplified reference tissue model to generate parametric images of [F]MPPF-binding potential (BPND). A significant reduction of [F]MPPF BPND was found in treated schizophrenic patients compared to age- and sex-matched healthy subjects. These modifications were mainly localized in the frontal and orbitofrontal cortex and may reflect either the pathophysiology of schizophrenia or medication effects. The schizophrenic patients treated with aripiprazole showed a reduction of global [F]MPPF BPND compared with healthy subjects and schizophrenic patients with SGA treatment. In addition, compared with matched controls, the reduction of regional [F]MPPF BPND was more marked in the schizophrenic patients treated with aripiprazole compared with those receiving SGA treatment, possibly reflecting the partial agonist of aripiprazole activity at 5-HT1A receptors.
Sujets
PID Serval
serval:BIB_3BFB78454845
PMID
Date de création
2018-11-29T11:36:57.107Z
Date de création dans IRIS
2025-05-20T14:38:36Z