Titre
Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Braissant, O.
Auteure/Auteur
Foufelle, F.
Auteure/Auteur
Scotto, C.
Auteure/Auteur
Dauça, M.
Auteure/Auteur
Wahli, W.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0013-7227[print], 0013-7227[linking]
Statut éditorial
Publié
Date de publication
1996-01
Volume
137
Numéro
1
Première page
354
Dernière page/numéro d’article
366
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily that can be activated by various xenobiotics and natural fatty acids. These transcription factors primarily regulate genes involved in lipid metabolism and also play a role in adipocyte differentiation. We present the expression patterns of the PPAR subtypes in the adult rat, determined by in situ hybridization using specific probes for PPAR-alpha, -beta and -gamma, and by immunohistochemistry using a polyclonal antibody that recognizes the three rat PPAR subtypes. In numerous cell types from either ectodermal, mesodermal, or endodermal origin, PPARs are coexpressed, with relative levels varying between them from one cell type to the other. PPAR-alpha is highly expressed in hepatocytes, cardiomyocytes, enterocytes, and the proximal tubule cells of kidney. PPAR-beta is expressed ubiquitously and often at higher levels than PPAR-alpha and -gamma. PPAR-gamma is expressed predominantly in adipose tissue and the immune system. Our results suggest new potential directions to investigate the functions of the different PPAR subtypes.
PID Serval
serval:BIB_10F152AF7054
PMID
Date de création
2008-01-24T15:04:53.321Z
Date de création dans IRIS
2025-05-20T15:18:18Z