Titre
Transient developmental expression of monoamine transporters in the rodent forebrain
Type
article
Institution
Externe
Périodique
Auteur(s)
Lebrand, C.
Auteure/Auteur
Cases, O.
Auteure/Auteur
Wehrle, R.
Auteure/Auteur
Blakely, R. D.
Auteure/Auteur
Edwards, R. H.
Auteure/Auteur
Gaspar, P.
Auteure/Auteur
Liens vers les personnes
ISSN
0021-9967
Statut éditorial
Publié
Date de publication
1998-11
Volume
401
Numéro
4
Première page
506
Dernière page/numéro d’article
24
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov 30
Research Support, Non-U.S. Gov't --- Old month value: Nov 30
Résumé
Neurons in first-order sensory thalamic nuclei have been shown to express functional plasma membrane serotonin (SERT) and vesicular monoamine (VMAT2) transporters during early postnatal development. In the present study, we provide an extensive description of the spatial and the temporal patterns of VMAT2 and SERT expression, during early embryonic development and postnatal life, by using in situ hybridization and immunocytochemistry. VMAT2 and SERT genes are transiently expressed in a wide population of non-monoaminergic neurons in the central and peripheral nervous system with a large overlap in the temporal and spatial pattern of expression of both genes. A selective pattern of expression of both genes was observed in the thalamus with expression limited to the dorsal thalamus and more particularly to primary sensory relay nuclei that convey point to point projection maps. Transient expression of the transporters was also observed in sensory cranial nerves, in the hippocampus, cerebral cortex, septum, and amygdala. VMAT2 and SERT gene expression was not necessarily linked, as some neural populations expressed only VMAT2, while others only contained SERT. Since VMAT2 serves to transport catecholamines besides serotonin, we examined the developmental expression of the plasma membrane dopamine and norepinephrine transporters but found no transient expression of these genes. Despite minor temporal disparities, VMAT2 and SERT extinguished almost simultaneously during the second and third weeks of post-natal life. These expressions did not seem to be dependent on peripheral neural inputs, since monocular enucleations and infraorbital nerve cuts effected on the day of birth, did not modify the period of transporter expression or of extinction.
Sujets
PID Serval
serval:BIB_547972F807D2
PMID
Date de création
2008-01-24T13:27:45.731Z
Date de création dans IRIS
2025-05-20T15:41:21Z