Titre
Contrast injection bradycardia during coronary angiography: effects in the denervated human heart.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Mukharji, J.
Auteure/Auteur
Thames, M.D.
Auteure/Auteur
Newton, M.
Auteure/Auteur
Hirsh, P.D.
Auteure/Auteur
Lewis, S.A.
Auteure/Auteur
Rehr, R.B.
Auteure/Auteur
Cowley, M.J.
Auteure/Auteur
Hess, M.L.
Auteure/Auteur
Hastillo, A.
Auteure/Auteur
Lower, R.R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0887-2570
Statut éditorial
Publié
Date de publication
1987
Volume
6
Numéro
1
Première page
44
Dernière page/numéro d’article
48
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
To assess the contribution of cardiac innervation toward understanding the mechanisms of bradycardia during contrast coronary angiography, heart rate (HR) responses in eight patients after heart transplantation were compared with 10 normal patients (control), 10 patients with coronary artery disease (CAD) and normal ventricular function, and 10 patients with congestive cardiomyopathy and normal coronary arteries. The longest P-P interval was measured beat to beat before (HR 1) and after (HR 2) coronary angiography. The coronary vessel perfusing the sinus node did not influence HR 2 responses within each group. HR 1 was significantly different from HR 2 (p less than 0.05) in the control and CAD groups but was not different in the transplant and cardiomyopathy groups. Compared with the control group, the percent decrease in HR was significantly less in transplant patients than in patients with cardiomyopathy. Thus contrast injection bradycardia is absent in denervated patients after heart transplant, and this response is markedly blunted in cardiomyopathy patients who are known to have diminished vasodepressor reflexes. These findings suggest that the bradycardia response is probably a neurally mediated phenomenon.
PID Serval
serval:BIB_378802DA3BE2
PMID
Date de création
2021-03-19T13:29:51.810Z
Date de création dans IRIS
2025-05-20T16:25:58Z