Titre
Regional Delta Waves In Human Rapid Eye Movement Sleep.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Bernardi, G.
Auteure/Auteur
Betta, M.
Auteure/Auteur
Ricciardi, E.
Auteure/Auteur
Pietrini, P.
Auteure/Auteur
Tononi, G.
Auteure/Auteur
Siclari, F.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1529-2401
Statut éditorial
Publié
Date de publication
2019-04-03
Volume
39
Numéro
14
Première page
2686
Dernière page/numéro d’article
2697
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Although the EEG slow wave of sleep is typically considered to be a hallmark of nonrapid eye movement (NREM) sleep, recent work in mice has shown that slow waves can also occur in REM sleep. Here, we investigated the presence and cortical distribution of negative delta (1-4 Hz) waves in human REM sleep by analyzing high-density EEG sleep recordings obtained in 28 healthy subjects. We identified two clusters of delta waves with distinctive properties: (1) a frontal-central cluster characterized by ∼2.5-3.0 Hz, relatively large, notched delta waves (so-called "sawtooth waves") that tended to occur in bursts, were associated with increased gamma activity and rapid eye movements (EMs), and upon source modeling displayed an occipital-temporal and a frontal-central component and (2) a medial-occipital cluster characterized by more isolated, slower (<2 Hz), and smaller waves that were not associated with rapid EMs, displayed a negative correlation with gamma activity, and were also found in NREM sleep. Therefore, delta waves are an integral part of REM sleep in humans and the two identified subtypes (sawtooth and medial-occipital slow waves) may reflect distinct generation mechanisms and functional roles. Sawtooth waves, which are exclusive to REM sleep, share many characteristics with ponto-geniculo-occipital waves described in animals and may represent the human equivalent or a closely related event, whereas medial-occipital slow waves appear similar to NREM sleep slow waves.SIGNIFICANCE STATEMENT The EEG slow wave is typically considered a hallmark of nonrapid eye movement (NREM) sleep, but recent work in mice has shown that it can also occur in REM sleep. By analyzing high-density EEG recordings collected in healthy adult individuals, we show that REM sleep is characterized by prominent delta waves also in humans. In particular, we identified two distinctive clusters of delta waves with different properties: a frontal-central cluster characterized by faster, activating "sawtooth waves" that share many characteristics with ponto-geniculo-occipital waves described in animals and a medial-occipital cluster containing slow waves that are more similar to NREM sleep slow waves. These findings indicate that REM sleep is a spatially and temporally heterogeneous state and may contribute to explaining its known functional and phenomenological properties.
PID Serval
serval:BIB_500BD059B81C
PMID
Open Access
Oui
Date de création
2019-03-25T09:23:42.094Z
Date de création dans IRIS
2025-05-20T16:27:24Z
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Nom
10.1523@JNEUROSCI.2298-18.2019.pdf
Version du manuscrit
preprint
Taille
8.53 MB
Format
Adobe PDF
PID Serval
serval:BIB_500BD059B81C.P001
URN
urn:nbn:ch:serval-BIB_500BD059B81C4
Somme de contrôle
(MD5):7848a2a4b5cdf617503cace3d4a079ee