Ets-1 maintains IL-7 receptor expression in peripheral T cells.

Ho, I.C.

doi:10.4049/jimmunol.1002099

Titre

Ets-1 maintains IL-7 receptor expression in peripheral T cells.

Type

article

Institution

Externe

Périodique

The Journal of Immunology

Auteur(s)

Grenningloh, R.

Auteure/Auteur

Tai, T.S.

Auteure/Auteur

Frahm, N.

Auteure/Auteur

Hongo, T.C.

Auteure/Auteur

Chicoine, A.T.

Auteure/Auteur

Brander, C.

Auteure/Auteur

Kaufmann, D.E.

Auteure/Auteur

Ho, I.C.

Auteure/Auteur

Liens vers les personnes

Kaufmann, Daniel

ISSN

1550-6606

Statut éditorial

Publié

Date de publication

2011-01-15

Volume

186

Numéro

2

Première page

969

Dernière page/numéro d’article

976

Peer-reviewed

Oui

Langue

anglais

Notes

Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Résumé

The expression of CD127, the IL-7-binding subunit of the IL-7 R, is tightly regulated during the development and activation of T cells and is reduced during chronic viral infection. However, the molecular mechanism regulating the dynamic expression of CD127 is still poorly understood. In this study, we report that the transcription factor Ets-1 is required for maintaining the expression of CD127 in murine peripheral T cells. Ets-1 binds to and activates the CD127 promoter, and its absence leads to reduced CD127 expression, attenuated IL-7 signaling, and impaired IL-7-dependent homeostatic proliferation of T cells. The expression of CD127 and Ets-1 is strongly correlated in human T cells. Both CD127 and Ets-1 expression are decreased in CD8(+) T cells during HIV infection. In addition, HIV-associated loss of CD127 is only observed in Ets-1(low) effector memory and central memory but not in Ets-1(high) naive CD8(+) T cells. Taken together, our data identify Ets-1 as a critical regulator of CD127 expression in T cells.