Titre

Impact of Waddlia chondrophila infection on pregnancy in the mouse.

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Baud, D.
Auteure/Auteur
Ammerdorffer, A.
Auteure/Auteur
Buffe, Y.
Auteure/Auteur
Vouga, M.
Auteure/Auteur
Greub, G.
Auteure/Auteur
Stojanov, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2052-2975
Statut éditorial
Publié
Date de publication
2020-01
Volume
33
Première page
100619
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
The intracellular bacterium Waddlia chondrophila, which belongs to the Chlamydiales order, was found to be associated with miscarriage in humans. There is little to no knowledge regarding the mode of infection, impact on the neonate and pathophysiology of this emerging bacterium. We have previously shown that W. chondrophila induces a systemic infection, organ pathology and elicits T helper type 1-associated humoral immunity in a murine model of genital infection. In the present study, we took advantage of this model of infection to evaluate the impact of this bacterium on the mouse pregnancy. We used two routes of inoculation, vaginal and intrauterine, to introduce infection before and after mating. Our results show that genital infection by W. chondrophila did not have any significant impact on gestation length and maternal weight gain, nor on the number of offspring and their weight. This observation indicates that the mouse model of infection is not suitable to study the effect of W. chondrophila on pregnancy and alternative models of infection, including in vitro ones, should be used. Moreover, an indirect immunopathological mechanism activated by this bacterium should be further explored.
Sujets

Adverse pregnancy out...

Waddlia chondrophila

chlamydiales

genital model

mouse

PID Serval
serval:BIB_172D1E764896
DOI
PMID
Permalien
Open Access
Oui
Date de création
2020-01-03T20:32:41.672Z
Date de création dans IRIS
2025-05-20T16:45:58Z
Fichier(s)
En cours de chargement...
Vignette d'image
Nom

31885870_BIB_172D1E764896.pdf

Version du manuscrit

published

Licence

https://creativecommons.org/licenses/by-nc-nd/4.0

Taille

451.63 KB

Format

Adobe PDF

PID Serval

serval:BIB_172D1E764896.P001

URN

urn:nbn:ch:serval-BIB_172D1E7648967

Somme de contrôle

(MD5):f05a12bfd1d010cc68c0b7750e702d1d