Titre
Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Bossen, C.
Auteure/Auteur
Ingold, K.
Auteure/Auteur
Tardivel, A.
Auteure/Auteur
Bodmer, J.L.
Auteure/Auteur
Gaide, O.
Auteure/Auteur
Hertig, S.
Auteure/Auteur
Ambrose, C.
Auteure/Auteur
Tschopp, J.
Auteure/Auteur
Schneider, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0021-9258
Statut éditorial
Publié
Date de publication
2006
Volume
281
Numéro
20
Première page
13964
Dernière page/numéro d’article
13971
Langue
anglais
Résumé
Ligands of the tumor necrosis factor superfamily (TNFSF) (4-1BBL, APRIL, BAFF, CD27L, CD30L, CD40L, EDA1, EDA2, FasL, GITRL, LIGHT, lymphotoxin alpha, lymphotoxin alphabeta, OX40L, RANKL, TL1A, TNF, TWEAK, and TRAIL) bind members of the TNF receptor superfamily (TNFRSF). A comprehensive survey of ligand-receptor interactions was performed using a flow cytometry-based assay. All ligands engaged between one and five receptors, whereas most receptors only bound one to three ligands. The receptors DR6, RELT, TROY, NGFR, and mouse TNFRH3 did not interact with any of the known TNFSF ligands, suggesting that they either bind other types of ligands, function in a ligand-independent manner, or bind ligands that remain to be identified. The study revealed that ligand-receptor pairs are either cross-reactive between human and mouse (e.g. Tweak/Fn14, RANK/RANKL), strictly species-specific (GITR/GITRL), or partially species-specific (e.g. OX40/OX40L, CD40/CD40L). Interestingly, the receptor binding patterns of lymphotoxin alpha and alphabeta are redundant in the human but not in the mouse system. Ligand oligomerization allowed detection of weak interactions, such as that of human TNF with mouse TNFR2. In addition, mouse APRIL exists as two different splice variants differing by a single amino acid. Although human APRIL does not interact with BAFF-R, the shorter variant of mouse APRIL exhibits weak but detectable binding to mouse BAFF-R.
PID Serval
serval:BIB_194DF0126EE5
PMID
Open Access
Oui
Date de création
2008-01-24T14:18:31.767Z
Date de création dans IRIS
2025-05-20T16:49:12Z
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Nom
BIB_194DF0126EE5.P001.pdf
Version du manuscrit
preprint
Taille
816.5 KB
Format
Adobe PDF
PID Serval
serval:BIB_194DF0126EE5.P001
URN
urn:nbn:ch:serval-BIB_194DF0126EE54
Somme de contrôle
(MD5):19a41d3d8b5c3da813e5085c428e0890