Titre
Positron emission tomography for the early postsurgical evaluation of pediatric brain tumors.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Pirotte, B.
Auteure/Auteur
Levivier, M.
Auteure/Auteur
Morelli, D.
Auteure/Auteur
Van Bogaert, P.
Auteure/Auteur
Detemmerman, D.
Auteure/Auteur
David, P.
Auteure/Auteur
Baleriaux, D.
Auteure/Auteur
Brotchi, J.
Auteure/Auteur
Goldman, S.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0256-7040
Statut éditorial
Publié
Date de publication
2005
Volume
21
Numéro
4
Première page
294
Dernière page/numéro d’article
300
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
OBJECT: The object was to study the value of postoperative positron emission tomography (PET) to assess the extension of brain tumor resection.
METHODS: Twenty children operated on for total resection of a glial tumor (18 low-grade, 2 anaplastic) presented a signal on postoperative magnetic resonance (MR) images raising the question of a possible tumor residue. PET was performed early ((18)F-Fluoro-deoxyglucose in 1, (11)C-methionine in 16, both in 3) to further characterize the nature of the abnormal MR signal in order to consider second-look surgery. An increased tracer uptake found in 14 children led to reoperation on 11 of them, confirming the tumor histologically. No (11)C-methionine uptake led to a conservative attitude in 6 children in whom MR imaging follow-up showed no tumor progression.
CONCLUSIONS: The early postoperative PET, especially with (11)C-methionine, appears to be a valid basis for complementary therapeutic decisions, especially second-look surgery, in glial tumors for which a radical resection is a key factor for prognosis.
METHODS: Twenty children operated on for total resection of a glial tumor (18 low-grade, 2 anaplastic) presented a signal on postoperative magnetic resonance (MR) images raising the question of a possible tumor residue. PET was performed early ((18)F-Fluoro-deoxyglucose in 1, (11)C-methionine in 16, both in 3) to further characterize the nature of the abnormal MR signal in order to consider second-look surgery. An increased tracer uptake found in 14 children led to reoperation on 11 of them, confirming the tumor histologically. No (11)C-methionine uptake led to a conservative attitude in 6 children in whom MR imaging follow-up showed no tumor progression.
CONCLUSIONS: The early postoperative PET, especially with (11)C-methionine, appears to be a valid basis for complementary therapeutic decisions, especially second-look surgery, in glial tumors for which a radical resection is a key factor for prognosis.
PID Serval
serval:BIB_4639F3EF49BD
PMID
Date de création
2008-01-20T16:35:37.259Z
Date de création dans IRIS
2025-05-20T17:26:59Z