Titre
Importance du profil clinique dans le dépistage de l'ostéoporose postménopausique par densitométrie. [Importance of the clinical profile in the postmenopausal osteoporosis screening by densitometry]
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Bigler, J.M.
Auteure/Auteur
Abetel, G.
Auteure/Auteur
Krieg, M.A.
Auteure/Auteur
Wimpfheimer, C.
Auteure/Auteur
Burnand, B.
Auteure/Auteur
Thiébaud, D.
Auteure/Auteur
Burckhardt, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0036-7672
Statut éditorial
Publié
Date de publication
1996
Volume
126
Numéro
31-32
Première page
1347
Dernière page/numéro d’article
1351
Peer-reviewed
Oui
Langue
français
Résumé
In order to test the impact of a given risk profile on the incidence of osteoporosis which could justify BMD measurement, and that of a low risk profile which could render it unnecessary, BMD was measured in 217 women under 72 in whom menopause had occurred at least 6 years previously and who corresponded to one of the two following profiles: high risk (A, n = 102) = BMI < 27 kg/m2, with no estrogen replacement treatment, and with at least one of the following risk factors: BMI < 20, early menopause, positive family history, no dairy products associated with tobacco consumption (> 10 cigarettes/day for > 20 years and/or alcohol consumption of > 0.5 l wine/day during > 10 years, corticotherapy of > 6 months, rickets, anorexia nervosa. Low risk (B, n = 115) = absence of characteristics of group A, BMI > 27 kg/m2 with (B+, n = 24) or without estrogen therapy (B-, n = 91). BMD was measured by DXA in 4 centers using Lunar or Hologic equipment. Results were expressed in % of the mean of the respective young adult control groups. As expected, BMD was significantly different in these two subgroups of the population. Osteoporosis was diagnosed (BMD < 75% = < -2.5 SD, according to WHO) in 72% of group A, and in 17% (B+) and 19% (B-) respectively of group B. There was no difference between the various risk factors in group A concerning their impact on BMD, but concerning incidence, low BMI and early menopause were the most frequent. The high risk profile of group A seems to justify densitometry, since it leads to the diagnosis of osteoporosis in over 70%. However, the protective profile of group B does not exclude osteoporosis (risk still 20%); only in severe obesity (BMI > 33) does it drop to 1%.
PID Serval
serval:BIB_5703
PMID
Date de création
2007-11-19T11:42:29.624Z
Date de création dans IRIS
2025-05-20T17:36:04Z