Titre
Effect of angiotensin II and of an angiotensin II analogue (Sar1-Ile8-angiotensin II) on blood pressure, plasma aldosterone and plasma renin activity in the dog
Type
article
Institution
Externe
Périodique
Clinical Science and Molecular Medicine. Supplement
Auteur(s)
Beckerhoff, R.
Auteure/Auteur
Uhlschmid, G.
Auteure/Auteur
Vetter, W.
Auteure/Auteur
Armbruster, H.
Auteure/Auteur
Nussberger, J.
Auteure/Auteur
Reck, G.
Auteure/Auteur
Schmied, U.
Auteure/Auteur
Siegenthaler, W.
Auteure/Auteur
Liens vers les personnes
ISSN
0144-4107
Statut éditorial
Publié
Date de publication
1975-06
Volume
2
Première page
41s
Dernière page/numéro d’article
44s
Notes
Journal Article --- Old month value: Jun
Résumé
1. The effect of infusions of equimolar doses of angiotensin II (AII) and of the angiotensin analogue Sar1-Ile8-angiotensin II on arterial blood pressure, plasma aldosterone and plasma renin activity were compared in normal anaesthetized dexamethasone suppressed dogs. 2. Angiotensin II induced a significant increase of blood pressure and of plasma aldosterone whereas plasma renin activity decreased. The blood pressure was only slightly affected by large doses of the analogue. Plasma aldosterone, however, increased and plasma renin activity decreased. These changes were significant but less pronounced than after the infusions of angiotensin II. Plasma aldosterone remained high and renin activity low for 40 min after the infusions of the analogue. 3. The results suggest a strong agonistic potency of Sar1-Ile8-angiotensin II at the adrenal and renal angiotensin receptors, and that it is almost ineffective at the vascular receptors. The inhibition of renin secretion by angiotensin seems not be related to its vasoconstrictive activity.
Sujets
PID Serval
serval:BIB_1C1270FF8484
PMID
Date de création
2008-03-05T15:39:36.835Z
Date de création dans IRIS
2025-05-20T18:11:51Z